Olivia Vizier

Execs Weigh In On Presidential Politics Impacting Biopharma

We at NeuBase have felt that there are fundamental deficiencies in the current approach to drug development. The traditional drug screening approach, which involves scouring libraries of chemicals and just seeing what works, is slow, costly, and ultimately translates to higher drug prices. We believe that there will be a revolution in the pharmaceutical industry

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Ensuring Patient-Friendly Clinical Trials For Complex Disorders — A Small Biopharma’s Playbook

Rezolute, a small company based in Redwood City, California, and working in the rare pediatric disease space, is developing a new therapeutic option specifically for patients with congenital hyperinsulinism (HI), an ultra-rare pediatric genetic disorder. For Rezolute, connecting and partnering with advocacy groups and physicians is paramount in clinical trial execution.

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Inhaled antibody drug for COVID-19 clears coronavirus in animals

Aridis Pharmaceuticals is working on an inhaled neutralizing antibody for COVID-19 dubbed AR-711, which was discovered using samples from patients who had recovered from COVID-19. The drug successfully cleared signs of SARS-CoV-2 virus from infected hamsters at a far lower dose compared with other experimental monoclonal antibodies, according to results published on preprint site bioRxiv.

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Mark Erlander of Cardiff Oncology, Inc. Discusses KRAS Mutations in Cancer

Mark Erlander, Chief Executive Officer at Cardiff Oncology, Inc. talks KRAS mutations in cancer, and existing products like mCRC, mCRPc and AML, along with three clinical programs including Zytiga-Resistant Metastatic Castration Resistant Prostate cancer (mCRPC); KRAS mutated Metastatic Colorectal Cancer (mCRC) and Relapsed/Refractory Acute Myeloid Leukemia (AML). You can find out more here.

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Antiviral Conjugates – A Novel Treatment and Prevention Strategy for Viral Diseases Including COVID-19

Cidara Therapeutics has adopted key immuno-oncology principles and applied them to infectious disease, enabling the creation of a novel antiviral strategy – antiviral conjugates (AVCs). AVCs are long-acting, bispecific drugs that directly inhibit viral proliferation, whilst simultaneously

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Developing Novel Treatments for CNS Diseases

Technology Networks recently spoke with Brad Margus, CEO at Cerevance, to find out how the company is addressing key drug development challenges. In this industry insight, Margus tells us more about the company’s drug development pipeline and their lead candidate CVN424, which is currently being developed to treat Parkinson’s disease. He also explains how Cerevance’s Nuclear

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San Diego biotechs have plunged into the fight against COVID-19. Here’s what they’re doing

Some of this work has already arrived, such as Helix’s COVID-19 test, which detects the coronavirus in thousands of samples collected at San Diego County test sites. Other efforts are several months away, including CalciMedica’s anti-inflammatory drug meant to help keep COVID-19 patients off ventilators; the biotech believes the treatment could be approved by May

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Q&A: Positive results with RNAi therapeutic for liver disease in patients with AATD

Arrowhead Pharmaceuticals Inc. announced 24-week liver biopsy results in patients from an open-label phase 2 clinical study of ARO-AAT, a second-generation investigational RNA interference therapeutic intended for treatment of a liver disease associated with alpha-1 antitrypsin deficiency.

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empowered

Novel Dual Action Treatment of Acute Cardiovascular Syndrome with Craig Fraser Windtree Therapeutics

Craig Fraser, CEO and President, Windtree Therapeutics talks about acute heart failure, the number one reason for hospitalization in people over 65 and the fact that there has been little innovation in trying to improve cardiac function. Developing a novel dual action drug called istaroxime, Windtree is addressing both parts of the cycles of the

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Pharma Technology Focus

Neutralising the Gluten Threat: Are we on the Cusp of a Coeliac Disease Breakthrough?

Named after the average length of the GI tract, 9 Meters’ larazotide is the first coeliac drug to enter Phase III trials. If things go to plan, larazotide could be approved by 2023, thereby overcoming the unmet needs that remain in this condition despite adherence to a gluten-free diet.

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Q&A with INmune’s Dr RJ Tesi: is TNF the key to treating the Covid-19 cytokine storm?

California-based INmune decided to leverage its TNF platform and launch a Phase II trial of its selective inhibitor of soluble TNF (sTNF), Quellor, in hospitalised Covid-19 patients. Quellor differs from the existing TNF inhibitors on the market, which are prescribed for inflammatory conditions ranging from rheumatoid arthritis, inflammatory bowel disease and psoriasis, because it only

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