At the inception of eFFECTOR, one of the key considerations was that, to extend the duration of benefit of a given treatment, you have to contend with resistance. It had become clear that, even when using the most tightly targeted therapy or immunotherapy, resistance happens. I’ve spent about 15 years in the antiviral world working with anti-infectives, mostly antivirals, and we experienced successes with both HIV and hepatitis C by really thinking hard about resistance and anticipating it ahead of time.