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Yahoo Finance Presents: Dr. Patrick Soon-Shiong

ImmunityBio Executive Chairman Dr. Patrick Soon-Shiong sat down with Yahoo Finance’s Anjalee Khemlani to discuss the recent growth of ImmunityBio, it’s work on a vaccine for the coronavirus, and the biotech industry.

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Fierce Pharma Asia—Takeda’s Anima mRNA translation pact, China digital health incubator; Daiichi’s COVID-19 vaccine

Takeda penned a potentially billion-dollar deal with Anima Biotech to work on mRNA translation modulators for neurological diseases. The Japanese pharma also launched a digital health incubator in Shanghai. Fellow Japanese drugmaker Daiichi Sankyo has ushered its mRNA COVID-19 vaccine into a phase 1/2 trial for initial safety and immunogenicity analysis. And more.

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GV wagers on seasoned team’s intranasal ‘temporary’ preventative approach to viruses — with ex-Gilead CEO John Martin jumping on board

Leyden Labs will focus on respiratory viruses with potential to cause pandemics, said Wiedhaup, who’s taking up the CEO role after a career spanning academia, biotech and consulting.

Can gene therapy be made to work against solid tumours?

Oncosec have developed another way of delivering genes to tumour cells without the need for viral vectors or nanoparticles. They have taken advantage of the electrotransfer method used by research laboratories to transfer DNA into cells. “When you put energy through the membrane of a cell, it causes it to become porous, and if you previously surrounded that cell with DNA plasmid, once you form those pores, the plasmids will move from outside the cell, through the membrane into the cell,” explains O’Connor.

Durect hit? DNMT inhibitor may have found home in AH

ProQR’s RNA therapy on track to pivotal tests in rare, inherited form of vision loss

ProQR Therapeutics has encouraging early data from a small study that show its experimental RNA-based therapy for a rare, inherited form of vision loss helped patients recover some of their sight. Based on those results, the company is planning to advance its therapy to two pivotal studies that could start later this year.

Targeting and Modulating CRAC Channels to Treat Acute Pancreatitis and COVID-19 with Dr. Sudarshan Hebbar CalciMedica

Dr. Sudarshan Hebbar, Chief Medical Officer, CalciMedica talks about developing drugs that are focused on targeting CRAC channels, calcium release activated calcium channels, in order to modulate these channels to help treat diseases that have a significant inflammatory component.  Initially developed drugs for acute pancreatitis targeting both the pancreas and the lung. Now conducting large trial in patients with severe and critical COVID-19 as many of the mechanisms that are shared in the development of lung disease with COVID-19 are shared with acute pancreatitis. Strong evidence that their drug Auxora  might be effective for a variety of disorders that cause lung injury.

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Clene is Using Nanocrystals of Pure Elements to Change Neurodegenerative Treatment

That is the mission of Clene Nanomedicine, which has combined cell biology, solid state physics, and materials science to pioneer the development of Clean-Surfaced Nanocrystal (CSN) therapeutics. The company’s goal is to use this process to enhance the energetic support in neurons and change the way neurodegenerative diseases are treated. PM360 spoke with President and CEO Rob Etherington about how this science works, how these treatments differ from the current standard of care for these diseases, and what this platform may mean for other therapeutic categories in the future.