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Targeting PVRIG in cancer immunotherapy

Compugen Ltd. recently presented new research data further supporting the PVRIG protein coding gene as a potentially promising target for cancer immunotherapy. These data suggest that PVRIG inhibition may enhance T cell priming and infiltration into tumors and provide further evidence supporting the potential advantages of targeting PVRIG—alone and in combination with TIGIT and PD-1 inhibitors—in tumors for which current checkpoint blockers have not proven successful.